Matthew E Kennedy Selected Research

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

11/2023	Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
1/2022	Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.

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Matthew E Kennedy Research Topics

Disease

16	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 08/2003
8	Parkinson Disease (Parkinson's Disease) 11/2023 - 12/2015
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2023 - 01/2022
1	Dementia (Dementias) 05/2023
1	Wounds and Injuries (Trauma) 01/2020
1	Edema (Dropsy) 01/2017
1	Disease Progression 01/2017
1	Amyloid Plaque 08/2003

Drug/Important Bio-Agent (IBA)

8	Amyloid (Amyloid Fibrils)IBA 09/2022 - 06/2014
7	Phosphotransferases (Kinase)IBA 11/2023 - 12/2015
6	Leucine (L-Leucine)FDA Link 11/2023 - 12/2015
5	verubecestatIBA 12/2020 - 11/2016
5	Peptides (Polypeptides)IBA 11/2016 - 08/2003
4	Proteins (Proteins, Gene)FDA Link 05/2023 - 06/2014
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 09/2022 - 08/2003
3	EnzymesIBA 12/2019 - 08/2003
2	Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA 11/2023 - 01/2022
2	Peptide Hydrolases (Proteases)FDA Link 01/2023 - 07/2014
1	Amyloid beta-PeptidesIBA 12/2023
1	Biomarkers (Surrogate Marker)IBA 05/2023
1	SynucleinsIBA 05/2023
1	Glucosylceramidase (Glucocerebrosidase)IBA 05/2023
1	LipidsIBA 05/2023
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 01/2017
1	AmidesIBA 12/2016

Therapy/Procedure

3	Therapeutics 11/2023 - 01/2020
1	Immunotherapy 01/2017